Department of Anatomy

University of Otago

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Departmental Seminar

Tuesday 24 November 2015

Time: 1-2pm
Venue: D’Ath Lecture Theatre, 1st Floor, Hercus Building

Dr Heather Cunliffe, Department of Pathology, University of Otago
“Triple negative breast cancer: From molecular insights to targeted therapies”
Triple negative breast cancer (TNBC) is the subgroup of tumours that do not express clinically significant levels of the estrogen receptor, progesterone receptor and the human epidermal growth factor 2 receptor. TNBCs typically respond well to chemotherapy, but have a higher frequency of early relapse with visceral and CNS metastases and poor survival.  We recently reported elevated expression of the androgen receptor (AR) in 23% of TNBCs, highlighting a potential molecularly-informed therapeutic strategy for these patients. This presentation will focus on our recent studies to define the genomic landscape and molecular subtypes of TNBCs.  This will include identification of the Androgen Receptor as attractive, molecularly informed therapeutic strategy and identification of the PDJ amplicon (PD-L1, PD-L2 and JAK2) as a poor prognostic indicator and potential therapeutic opportunity in high-risk TNBC.

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